The following is a nearly comprehensive list of buildings on the campus of UMass Amherst since its founding as the Massachusetts Agricultural College, though omitting most barns and out-buildings. In 2009, the Facilities and Campus Planning Department commissioned an historic resources inventory for all buildings on campus over 50 years old, making recommendations regarding eligibility for inclusion in the National Register of Historic Places.

• Abigail Adams House, built 1919/1920.
• Agricultural Engineering Building, North, built 1915
• Agricultural Experiment Station, built 1923
• Apiary, built 1911.
• Arnold House, built 1954.
• Baker House, built 1952.
• Bartlett Hall, built 1960.
• Berkshire House, built 1948.
• Blaisdell House, built 1869.
• Boarding House, built 1867.
• Botanic Museum, built 1867.
• Bowditch Hall, built 1959.
• Bowditch Lodge, built 1937.
• Boyden Physical Education Building, built 1963/1964.
• Brett House, built 1962/1963.
• Brooks House, built 1949.
• Brooks Tobacco Barn, built 1924.
• Butterfield House, built 1940/1941
• Campus Center, built 1970. (Named for alumnus Murray D. Lincoln, national leader in consumer and producer cooperatives and founder and president of CARE from 1945-1957)
• Campus Center Parking Garage, built 1970.
• Cance, built 1968.
• Cashin, built 1971.
• Cavalry Barn, built 1920; burns and rebuilt 1925.
• Chadbourne House, built 1947.
• Chancellor's House, built 1883-1884. (Originally called “Hillside House”, a name dropped in the 1960s, but revived in 1993)
• Chemistry Laboratory, built 1867; burned 1922.
• Chenoweth Laboratory, built 1930.
• Clark Hall, built 1907
• Commonwealth Circle, built 1946.
• Conte Center for Polymer Research, built 1996. (Named for Silvio O. Conte, a former U.S. congressman who was committed to polymer research and was instrumental in obtaining federal funding to build the complex)
• Coolidge, built 1966.
• County Circle, built 1946?.
• Crabtree House, built 1953.
• Crampton, built 1966/1967.
• Curry Hicks Gymnasium, built 1931
• Dickinson Hall, built 1960.
• Dickinson House, built 1965.
• Dining Commons, North, built 1954.
• Dining Commons, South, built 1965.
• Draper Hall, built 1903.
• Draper Hall Annex, built 1947.
• Drill Hall, built 1883.
• Du Bois Library
• Durfee Conservatory, built 1954
• Durfee Plant House, built 1867.
• Dwight, built 1959.
• East Experiment Station, built 1889-1890
• Emerson, built 1966.
• Engineering Annex, destroyed by fire 1948.
• Engineering Building, built 1955.
• Engineering Building, East, built 1965.
• Engineering Shop, built 1916.
• Engineering Shop (Mechanical), built 1962.
• Farley 4H Clubhouse, built 1934.
• Federal Circle, built 1946.
• Fernald Hall, built 1910.
• Field House, built 1965.
• Fine Arts Center, built 1975
• Fisher Laboratory, built 1911/1912, demolished after fire, 1985.
• Flint Laboratory, built 1912.
• Franklin Dining Commons, built 1965
• French Hall, built 1909.
• Goessmann Laboratory, built 1922/1924.
• Goodell Hall, built 1935. (Named after Henry Hill Goodell, professor of modern languages and the first college librarian, who became the seventh president of Massachusetts Agricultural College)
• Gorman House, built 1962/1963.
• Graduate Research Center, built 1971.
• Grayson House, built 1965.
• Greenough House, built 1946/1947.
• Grinnell Arena, built 1911/1912.
• Gunness Laboratory, built 1949.
• Hamden Dining Hall, built 1967.
• Hamlin House, built 1949.
• Hampshire Dining Hall, built 1966.
• Hampshire House, built 1948.
• Harlow Barn, built ca.1910.
• Hasbrouck Laboratory, built 1950 ?.
• Hatch Laboratory, built 1891.
• Herter Hall, built 1969 (Named for Christian A. Herter, Governor of Mass., 1953-1957)
• Hills House, built 1960.
• Hillside House, built 1883-1884
• Holdsworth Hall, built 1963.
• Homestead, built 1761 (circa).
• Horse Barn, built 1894.
• Infirmary (1st.), built 1915.
• Infirmary (2nd), built 1961/1962. Opened Jan. 1962
• Infirmary Annex (2 story wooden), built 1947.
• Insectary, built 1889.
• James, built 1966.
• John Adams, built 1966.
• John Quincy Adams, built 1966.
• Johnson House, built 1960.
• Kennedy, built 1966.
• Knowles Engineering, built 1991. (Named for Andrew C. Knowles III, former chairman of the Board of Trustees and a 1957 Graduate of the College of Engineering)
• Knowlton House, built 1949/1950.
• Leach House, built 1953.
• Lewis House, built 1940.
• Liberal Arts Annex, built 1947 (temporary).
• Lincoln Apartments, built 1958.
• Lyon, built 1959.
• Machmer Hall, built 1957.
• Mackimmie, built 1966/1967.
• Mahar Auditorium, built 1965.
• Maintenance Building, built 1960.
• Marks Meadow, built 1962.
• Marshall Hall, built 1915/1916.
• Marshall Hall Annex, built 1947.
• Marston Hall, built 1950, 1954
• Mary Lyon House, built 1959.
• McIntire House, built 1928.
• McNamara, built 1971.
• McQuirk Alumni Stadium
• Melville, built 1966.
• Memorial Hall, built 1920-1921. (Commemorates the service of alumni and faculty who died in World War I)
• Middlesex, built 1948.
• Millis House, built 1948/1949.
• Mobile Units (5) Music Dept., built 1965.
• Montague House, built 1840 (circa).
• Moore, built 1968.
• Morrill Science Center (4 buildings), built 1959, 1960, 1962, 1966.
• Mullins Center
• Munson Hall, built 1898. (Named for Williard A. Munson, Director of Extension Service, 1926-1950)
• Murray D. Lincoln Campus Center, built 1970. (Named for alumnus Murray D. Lincoln, national leader in consumer and producer cooperatives and founder and president of CARE from 1945-1957)
• Newman Center, built 1963.
• North College, built 1868, razed 1955 to make way for Machmer Hall.
• North Village.
• Observatory, built 1965.
• Old Chapel, built 1884-1886
• Paige Laboratory, built 1950.
• Patterson, built 1966/1967.
• Photo Laboratory, built 1907.
• Physical Plant, built 1959.
• Pierpont, built 1968.
• Plymouth, built 1948.
• Pomology Shed, built 1947
• Pond
• Power Plant, built 1903.
• President's House, built 1885.
• Prince, built 1966 or 1967.
• Public Health Building, built 1958.
• Robsham Memorial Center for Visitors, built 1989. (Named for a former member of the Board of Trustees, Paul Robsham, who together with his wife donated the funds for this building in memory of their son)
• School of Business Administration, built 1963.
• School of Business Administration, built 1965.
• School of Education, built 1961.
• Security Building, built 1965.
• Shade Tree Laboratory, built 1949.
• Skinner Hall, built 1948; dedicated Apr. 1949
• South College, built 1867; burned and rebuilt, 1885.
• Southwest Residential Complex, built 1966.
• Stockbridge Hall, built 1914 or 1915 ?. (Named for Levi Stockbridge, the University's first Professor of Agriculture and its 3rd [permanently seated] president)
• Stockbridge House, built 1728
• Student Union, built 1957.
• Suffolk, built 1948.
• Sylvan Residential Area
• Thatcher House, built 1935.
• Thayer laboratory, built 1953, 1957.
• Thompson Hall, built 1968.
• Thoreau, built 1966.
• Tillson House, built 1926
• Tobin Hall, built 1972.
• Trolley Station, built 1911 or 1915?
• University Library, built 1972. Opened 1973
• Van Meter House, built 1957.
• Veterinary Science Building, built 1899.
• W.E.B. Du Bois Library, built 1971-1973. Opened 1973 (Named for civil rights activist W.E.B. Du Bois)
• Waiting Station, built 1911 or 1915?.
• Washington, built 1966.
• Waskiewicz House, built 1958
• Webster House, built 1965.
• West Experiment Station, built 1885/1886 [1886-1887].
• Wheeler House, built 1958.
• Whitmore Hall, built 1966-1967. (Named for Phillip Whitmore, who served the University as an Alumni Association president, trustee and a state representative)
• Wilder Hall, built 1903 or 1906 ?.
• Women's Physical Education Building, built 1958/1959.
• Worcester Dining Hall, built 1953